Fanconi anemia proteins and endogenous stresses
نویسندگان
چکیده
منابع مشابه
SnapShot: Fanconi Anemia and Associated Proteins
Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. Th...
متن کاملFanconi anemia
What is it? Fanconi anemia (FA) is an autosomal recessive human disease characterized by congenital malformations, bone marrow failure and cancer. FA patients often develop leukemia and/or squamous cell carcinomas of the head and neck or gynecologic system. FA cells are hypersensitive to DNA crosslinking agents, such as mitomycin C (MMC) or diepoxybutane (DEB), and the syndrome is believed to r...
متن کاملFanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle
In recent years, Fanconi anemia (FA) has been the subject of intense investigations, primarily in the DNA repair research field. Many discoveries have led to the notion of a canonical pathway, termed the FA pathway, where all FA proteins function sequentially in different protein complexes to repair DNA cross-link damages. Although a detailed architecture of this DNA cross-link repair pathway i...
متن کاملFanconi Anemia Proteins Function in Mitophagy and Immunity
Fanconi anemia (FA) pathway genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear DNA. Here, we describe an essential role for FA genes in two forms of selective autophagy. Genetic deletion of Fancc blocks the autophagic clearance of viruses (virophagy) and increases susceptibility to lethal viral encephalitis. Fanconi anemia complementation group ...
متن کاملRegulated binding of the Fanconi anemia proteins, FANCA and FANCC.
In a recent article in BLOOD, Kruyt and Youssoufian1 examined the cellular localization and possible interaction of the Fanconi anemia (FA) proteins, FANCA and FANCC. There are several inconsistencies between their data and our published work.2 We would like to clarify our results and offer an explanation for the new discordant data. Several studies support the existence of a physical interacti...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2009
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2009.03.013